ANGPTL4 Prevents Atherosclerosis by Preserving KLF2 to Suppress EndMT and Mitigates Endothelial Dysfunction
These findings identify ANGPTL4 as a critical modulator of endothelial inflammation and EndMT via suppression of TGF-β-Smad2 signaling and restoration of KLF2. By preserving vascular integrity and promoting endothelial homeostasis, ANGPTL4 may serve as a preventive modulator in EndMT-driven vascular pathology and coronary microvascular dysfunction.
Authors
- Meeyoung Cho (ORCID: https://orcid.org/0000-0003-0697-6867)
- Bo Gyeong Kang (ORCID: https://orcid.org/0000-0003-3883-8418)
- Ju Hee Jun
- Hyang Hee Cho
- Yong Sook Kim (ORCID: https://orcid.org/0000-0001-9483-5639)
- Joon Ho Ahn (ORCID: https://orcid.org/0000-0003-3465-6596)
- Youngkeun Ahn (ORCID: https://orcid.org/0000-0003-2022-9366)
- Jin Young Yoo (ORCID: https://orcid.org/0000-0003-0007-1960)
- Soo Ji Yoo
- Hyung-Seok Kim (ORCID: https://orcid.org/0000-0002-8297-9747)
- Isabella Hwang
- Dong Im Cho
Institutions
- Chonnam National University (KR)
- Chonnam National University Hospital (KR)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1161/atvbaha.125.322700
- Citations
- 4
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.55