Cardiovascular damage, arrhythmogenesis and overlapping Alzheimer and Parkinson's diseases and TDP-43 pathology start in pediatric and young adult urban populations: Magnetic ultrafine particulate matter and industrial particles with motion behavior

Cardiac damage and neurodegeneration simultaneously evolve in children and young adults, exposed to environmental oxidative, magnetic, motion capable, ultrafine particulate matter (UFPM) and industrial nanoparticles (NPs). Particles move in situ when exposed to DC/AC magnetic 30-50 μT fields, and are documented in fetal hearts, brains and placentas. We identify magnetic NPs and measured motion behavior under AC and DC fields in ventricles, septum, atrioventricular (AV) conduction axis, auricles and ventricles, in healthy hearts of 18 Metropolitan Mexico City (MMC) 30.4 ± 9.4y olds with Alzheimer's, Parkinson's and/or TDP-43 neuropathology. Saturation isothermal remanent magnetization (SIRM), capturing magnetic FeNPs ̴ 20 nm, was recorded in all samples. Type 1 motion responses were identified in 19/35 samples under 25 mT with an x-direction 2.9° variation orientation. Movement 4.7 to 13.4° identified Type 2 motion, while ≥90° (Type 3) supported material moving erratically. AV samples exhibited Type 2 motion with high and low coercivity particles: the latter capable of interacting with low magnetic fields and carrying a high arrhythmogenesis risk. UFPM/NPs produce oxidative stress and striking tissue retention and magnetic effects. Superparamagnetic UFPM/NPs 7-25 nm produce magnetic hyperthermia that could be subjected to remote temperature and motion induction through natural and human-made static and alternating, pulsating dynamic electromagnetic fields i.e., power lines, electrical wiring, radiofrequency radiation (wireless telecommunication devices and equipment). Distinctive magnetic behavior and ferrimagnetic/antiferrimagnetic properties could have a critical impact on heart responses to electromagnetic fields. Cardiac and neurotoxic NPs burden are connected. We should focus towards prenatal and paediatric CVD and neurodegenerative diseases' prevention.