SIGIRR Alleviates Intestinal Mucosal Damage in Severe Acute Pancreatitis via the TLR4 Signaling Pathway
SIGIRR plays a protective role in SAP by preserving intestinal barrier integrity and negatively regulating the TLR4 signaling pathway. Targeting SIGIRR offers a novel approach for improving SAP.
Authors
- Feng Zhou (ORCID: https://orcid.org/0000-0003-3548-735X)
- Yanping Song (ORCID: https://orcid.org/0000-0002-3070-002X)
- Bowen Cheng (ORCID: https://orcid.org/0000-0001-7470-8077)
- Xiaojiang Zhou (ORCID: https://orcid.org/0000-0003-4622-6040)
- Dingwei Liu (ORCID: https://orcid.org/0000-0001-8402-4162)
- Shenglong Wei
- Yang Liu (ORCID: https://orcid.org/0000-0002-6872-6815)
- Yong Xie (ORCID: https://orcid.org/0000-0002-5939-5882)
- Huifang Xiong
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101608
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00