Electrophysiological changes in the acute phase after deep brain stimulation surgery
The transient postoperative microlesional effect is characterized by reduced beta band power and reduced neural signal complexity that gradually stabilize towards the end of the first month after surgery and most likely reflect local neuronal adaptation. These findings are important for the timing of electrophysiology-supported DBS programming, such as contact selection or adaptive algorithms.
Authors
- Andrea A. Kühn (ORCID: https://orcid.org/0000-0002-4134-9060)
- Hayriye Cagnan (ORCID: https://orcid.org/0000-0002-1641-115X)
- Jeroen Habets (ORCID: https://orcid.org/0000-0002-1015-093X)
- Valentina D’Onofrio (ORCID: https://orcid.org/0000-0002-5898-0967)
- Lucia K. Feldmann (ORCID: https://orcid.org/0000-0003-1290-208X)
- Katharina Faust (ORCID: https://orcid.org/0000-0001-9969-0141)
- Georg Ebersbach (ORCID: https://orcid.org/0000-0003-3403-6987)
- Diogo C. Soriano (ORCID: https://orcid.org/0000-0002-9804-7477)
- Gerd‐Helge Schneider (ORCID: https://orcid.org/0000-0002-1301-2938)
- Varvara Mathiopoulou (ORCID: https://orcid.org/0000-0002-5768-4277)
- Doreen Gruber (ORCID: https://orcid.org/0009-0009-4335-4718)
- Jonathan Kaplan (ORCID: https://orcid.org/0000-0002-0821-7939)
Institutions
- University of Padua (IT)
- Düsseldorf University Hospital (DE)
- Neurologisches Fachkrankenhaus für Bewegungsstörungen/Parkinson (DE)
- Heinrich Heine University Düsseldorf (DE)
- Imperial College London (GB)
- Universidade Federal do ABC (BR)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.brs.2025.08.002
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dystonia Medical Research Foundation
- Deutsche Forschungsgemeinschaft
- Lundbeckfonden
- H. Lundbeck A/S