Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes
Donor intrahepatic microbial DNA signature predicts LT outcomes via immune-metabolic modulation. While causality requires further study, these findings position the graft microbiome as a novel biomarker and potential therapeutic target, paving the way for microbiome-informed precision care in transplantation.
Authors
- Pablo Pelegrı́n (ORCID: https://orcid.org/0000-0002-9688-1804)
- L. Martínez‐Alarcón (ORCID: https://orcid.org/0000-0001-7497-6709)
- Víctor López‐López (ORCID: https://orcid.org/0000-0003-1718-3352)
- Pedro Cascales (ORCID: https://orcid.org/0000-0001-6703-6372)
- Felipe Alconchel (ORCID: https://orcid.org/0000-0002-5483-0312)
- J.A. Pons (ORCID: https://orcid.org/0000-0001-5017-7240)
- Marta Jover-Aguilar
- Sandra V. Mateo (ORCID: https://orcid.org/0000-0002-5496-3705)
- Antonio Ríos (ORCID: https://orcid.org/0000-0001-5512-9010)
- Alberto Baroja‐Mazo (ORCID: https://orcid.org/0000-0001-5212-5006)
- Fernando Lucas‐Ruiz (ORCID: https://orcid.org/0000-0002-8799-6909)
- Daniel Vidal-Correoso (ORCID: https://orcid.org/0009-0005-6988-4267)
- Pablo Ramírez (ORCID: https://orcid.org/0000-0002-0137-9038)
- María Magdalena de la Torre-Álamo
Institutions
- Instituto Murciano de Investigación Biosanitaria (ES)
- Hospital Universitario Virgen de la Arrixaca (ES)
- Universidad de Murcia (ES)
Publication Details
- Journal
- Gut
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1136/gutjnl-2025-335986
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundación Mutua Madrileña
- Comunidad Autónoma de la Región de Murcia
- Instituto de Salud Carlos III