IgE-activated human lung mast cells preferentially release prostaglandin D2, thromboxane A2, and cysteinyl-leukotrienes
There is a high degree of specialization in HLMC with a strong and specific increase in cysteinyl leukotrienes and PGD<sub>2</sub> but also the bronchoconstrictor thromboxane A<sub>2</sub> after IgE-dependent activation.
Authors
- Johan Kolmert (ORCID: https://orcid.org/0000-0001-7116-6583)
- Gunnar Nilsson (ORCID: https://orcid.org/0000-0001-6795-5512)
- Barbro Dahlén (ORCID: https://orcid.org/0000-0003-3803-9034)
- Elin Rönnberg (ORCID: https://orcid.org/0000-0002-4628-9968)
- Erik Sachs (ORCID: https://orcid.org/0000-0003-4178-7201)
- Jesper Säfholm (ORCID: https://orcid.org/0000-0003-1922-8104)
- Mamdoh Al‐Ameri (ORCID: https://orcid.org/0000-0002-4327-8825)
- Craig E. Wheelock (ORCID: https://orcid.org/0000-0002-8113-0653)
- Anna‐Karin Johnsson (ORCID: https://orcid.org/0000-0002-0018-700X)
- Kasra Vali Jalali
Institutions
- Karolinska University Hospital (SE)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.jaci.2025.07.026
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Åke Wiberg Stiftelse
- Torsten Söderbergs Stiftelse
- European Federation of Pharmaceutical Industries and Associations
- Konsul Th C Berghs Stiftelse
- Cancerfonden
- Hjärt-Lungfonden
- Stockholms Läns Landsting
- Vetenskapsrådet
- Magnus Bergvalls Stiftelse
- Astma- och Allergiförbundet
- HORIZON EUROPE Framework Programme