Deciphering estrogen receptor alpha–driven transcription in human endometrial stromal cells via transcriptome, cistrome, and integration with chromatin landscape
The CRISPR-mediated ESR1 activation restores estrogen responsiveness in endometrial stromal cells. Combined transcriptomic, cistromic, and chromatin architecture analyses reveal ESR1's role in regulating decidualization and inflammation-related gene networks, with relevance to endometrial pathologies including endometrial cancer. This model serves as a powerful tool to study estrogen signaling in endometrial stromal cell biology and related pathologies.
Authors
- Abhinav K. Jain (ORCID: https://orcid.org/0000-0003-3268-514X)
- Austin Bell‐Hensley (ORCID: https://orcid.org/0000-0003-1498-3012)
- Abdull J. Massri (ORCID: https://orcid.org/0000-0003-1314-6650)
- Shuyun Li (ORCID: https://orcid.org/0000-0002-6172-784X)
- Francesco J. DeMayo (ORCID: https://orcid.org/0000-0002-9480-7336)
- MyeongJin Yi (ORCID: https://orcid.org/0000-0002-6561-3620)
- Skylar Montague Redecke (ORCID: https://orcid.org/0000-0002-1418-8863)
Institutions
- National Institute of Environmental Health Sciences (US)
Publication Details
- Journal
- F&S Science
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.xfss.2025.08.002
- Citations
- 1
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.80