Heat shock protein 90 mediates the protective effects of vericiguat on myocardial ischemia/reperfusion injury by inhibiting toll-like receptor 4 and c-Jun N-terminal kinases.
HSP90 mediates the cardioprotective effects of vericiguat, potentially by inhibiting TLR4, JNK activation, and inflammatory responses.
Authors
- Ronghui Tu
- Sining Pan (ORCID: https://orcid.org/0000-0002-5409-3367)
- Zhiyu Zeng (ORCID: https://orcid.org/0000-0002-7383-2700)
- Min Wang (ORCID: https://orcid.org/0000-0002-7268-5139)
- Dongxiao Wang (ORCID: https://orcid.org/0000-0001-5358-196X)
- Guoqiang Zhong (ORCID: https://orcid.org/0000-0003-4565-1862)
- Junyan Chen (ORCID: https://orcid.org/0000-0003-3903-6783)
- Jian‐Jun Meng
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.84354.18248
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangxi Province