Human Single-Nucleus RNA Sequencing Identifies CD47 as a Therapeutic Target for Doxorubicin-Induced Cardiomyopathy
Our data support CD47 as a disease-specific target and promising therapeutic approach for mitigating cardiac dysfunction in DoxCM.
Authors
- Amanda Klaas
- Kenneth B. Margulies (ORCID: https://orcid.org/0000-0002-8093-4465)
- Kory J. Lavine (ORCID: https://orcid.org/0000-0003-1948-9945)
- B. Alexander Yi (ORCID: https://orcid.org/0000-0003-4888-2391)
- Alireza Sargazi (ORCID: https://orcid.org/0000-0003-1937-6051)
- Ali Javaheri (ORCID: https://orcid.org/0000-0001-6657-331X)
- Ahmed Diab (ORCID: https://orcid.org/0000-0002-1891-3620)
- Sumanth D. Prabhu (ORCID: https://orcid.org/0000-0002-7247-7241)
- Lauren N. Pedersen (ORCID: https://orcid.org/0000-0003-0313-3311)
- Carmen Bergom (ORCID: https://orcid.org/0000-0002-0886-5055)
- Zhen Guo (ORCID: https://orcid.org/0000-0002-8421-4852)
- Mualla Özcan (ORCID: https://orcid.org/0000-0002-1763-5454)
- Mengcheng Shen (ORCID: https://orcid.org/0000-0001-7037-6159)
- Jeffrey J. Szymanski (ORCID: https://orcid.org/0000-0002-8005-701X)
- Mandy M. Chan (ORCID: https://orcid.org/0000-0001-6511-0962)
- Benjamin J. Kopecky (ORCID: https://orcid.org/0000-0002-9087-6254)
- Craig T. Basson (ORCID: https://orcid.org/0000-0003-0211-4936)
- Hamidreza Hajirezaei (ORCID: https://orcid.org/0000-0001-9023-4262)
- Attila D Kovács (ORCID: https://orcid.org/0000-0003-2320-6434)
- Pierre Signore
- Pan Ma (ORCID: https://orcid.org/0000-0002-0815-849X)
- Aynaz Lotfinaghsh (ORCID: https://orcid.org/0009-0005-8712-2020)
- Adnan Imam (ORCID: https://orcid.org/0009-0003-7499-4941)
- Babak Razani (ORCID: https://orcid.org/0000-0002-7172-9240)
- Marco Sardiello (ORCID: https://orcid.org/0000-0001-6484-0250)
- Joel D. Schilling (ORCID: https://orcid.org/0000-0002-3884-1994)
- Yoon-Je Cho (ORCID: https://orcid.org/0000-0001-9641-8572)
- Omid Rashidi (ORCID: https://orcid.org/0000-0002-4588-8731)
- Aarti H. Asnani (ORCID: https://orcid.org/0000-0003-4967-9918)
- Kodi S. Ravichandran (ORCID: https://orcid.org/0000-0001-9049-1410)
- Anahita Ataran (ORCID: https://orcid.org/0000-0003-4426-4959)
- Felicia Grogan
- Wenjing Yu
- Shannon Kelley (ORCID: https://orcid.org/0000-0002-0381-2050)
- Alexander Pompian
- Rehman Lodhi
- Carla Valenzuela Ripoll (ORCID: https://orcid.org/0000-0002-6177-5227)
- Amen Bekele Zelleke
Institutions
- Beth Israel Deaconess Medical Center (US)
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- Cardiovascular Institute of the South (US)
- Hospital of the University of Pennsylvania (US)
- Beth Israel Deaconess Hospital (US)
- Anna Needs Neuroblastoma Answers (US)
- Stanford Medicine (US)
- John Cochran VA Medical Center (US)
- Hesco (United States) (US)
- University of Pennsylvania (US)
- University of Colorado Denver (US)
- Stanford University (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1161/circulationaha.124.071217
- Citations
- 4
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.56