Reversal of amino acid metabolism patterns between circulating blood and tumors as a new biomarker for the Zhengxu Xieshi syndrome in patients with esophageal squamous cell carcinoma.
This study presents a new perspective on the prevalence of ZXXS syndrome in patients with ESCC, contextualized within the realm of metabolic reprogramming. Specifically, diminished amino acid metabolism in the circulating blood corresponds to a deficiency in vital <i>Qi</i>. Conversely, hyperactive amino acid metabolism in ESCC tissues signifies an augmentation of local evil <i>Qi</i>. These findings hold potential to enrich the current medical framework and offer a deeper understanding of ESCC management by integrating the principles of ZXXS syndrome.
Authors
- Jun Pan (ORCID: https://orcid.org/0000-0002-0341-9953)
- Xing Jin (ORCID: https://orcid.org/0000-0003-2942-1469)
- Siliang Wang (ORCID: https://orcid.org/0000-0003-1228-869X)
- Changsheng Dong (ORCID: https://orcid.org/0000-0001-8385-7904)
- Xi Yang (ORCID: https://orcid.org/0000-0001-6125-7641)
- Wenyuan Jia
- Peijuan Wang (ORCID: https://orcid.org/0000-0003-3648-1355)
- Lei Liu (ORCID: https://orcid.org/0000-0002-3570-2219)
- Congcong Wang (ORCID: https://orcid.org/0000-0003-1793-3301)
- Qiang Jin (ORCID: https://orcid.org/0000-0001-8065-3543)
- Zheng Miaomiao
- X U Hanchen
- Chen Wenlian
- M A Yushui
- Qin Chentai
Institutions
- Nanjing General Hospital of Nanjing Military Command (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-08-01
- DOI
- https://doi.org/10.19852/j.cnki.jtcm.2025.04.020
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00