Evolving treatment strategies for invasive Streptococcus pyogenes in children in the postpandemic era

Our findings highlight how treatment strategies and disease patterns have shifted in the postpandemic period. Pneumonia with a parapneumonic abscess or empyema has emerged as the most frequent clinical presentation, with nearly half of such cases requiring second-line linezolid therapy. Linezolid may be a valuable treatment alternative after beta-lactam and clindamycin failure. IVIG has been used in severe cases but often late, warranting further investigation into its optimal application.