The immunologic landscape of HRAS-mutant head and neck squamous-cell carcinoma
HRAS-mut HNSCCs are characterized by a significantly increased number of pre-exhausted PD-1(+) TCF1(+) T cells and PD-L1 expression, suggesting a potential sensitivity to immunotherapy.
Authors
- A. Psyrri
- Maria Papageorgiou (ORCID: https://orcid.org/0000-0002-9943-6976)
- Anastasios Pantazopoulos (ORCID: https://orcid.org/0000-0002-9052-3416)
- Alexandra Margeli
- Georgia Gomatou (ORCID: https://orcid.org/0000-0002-1031-8261)
- P. Economopoulou
- I. Kotsantis
- Μaria Anastasiou (ORCID: https://orcid.org/0000-0003-0047-8090)
- Aris Spathis (ORCID: https://orcid.org/0000-0001-8867-3661)
- Anastasios Kyriazoglou (ORCID: https://orcid.org/0000-0003-3222-4060)
- Θεόδωρος Ράμπιας (ORCID: https://orcid.org/0000-0002-5460-5334)
- P Foukas
Institutions
- National and Kapodistrian University of Athens (GR)
- Academy of Athens (GR)
- University General Hospital Attikon (GR)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105538
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National and Kapodistrian University of Athens