Efficient Fine-Tuning of Endothelial Gene Expression by a Single Tyrosine (Y <sup>685</sup> ) to Phenylalanine Point Mutation in the VE-Cadherin Gene
Overall, our results indicate a novel regulatory mechanism for transcriptional signatures in lung tissue, involving the critical site Y<sup>685</sup> of VE-cadherin. This finding offers future insights for precision medicine applications.
Authors
- Donald Martin (ORCID: https://orcid.org/0000-0001-5913-2372)
- Aude Durand (ORCID: https://orcid.org/0009-0003-7869-3214)
- Arnold Fertin (ORCID: https://orcid.org/0000-0001-9563-9103)
- Olivia Garnier
- Sarah Berndt (ORCID: https://orcid.org/0000-0002-9975-9628)
- Gilles Carpentier (ORCID: https://orcid.org/0000-0002-3730-7263)
- Christophe Battail (ORCID: https://orcid.org/0000-0001-6849-7824)
- Isabelle Vilgrain (ORCID: https://orcid.org/0000-0002-5511-5871)
- Florian Jeanneret (ORCID: https://orcid.org/0000-0002-9301-4019)
Institutions
- Institut polytechnique de Grenoble (FR)
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Paris-Est Sup (FR)
- CEA Grenoble (FR)
- Direction de la Recherche Technologique (FR)
- National Institute of Health (AM)
- Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires (FR)
- Laboratoire d'Électronique des Technologies de l'Information (FR)
- Institut de Biosciences et Biotechnologies (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1161/atvbaha.125.323129
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00