Evaluating Bilateral Symptom Relief Following Parasagittal Interlaminar Epidural Steroid Injections

Parasagittal ILESIs provide more consistent and substantial relief of ipsilateral lumbar radicular symptoms. Contralateral relief is less predictable and may be limited by needle placement and the spread of medication. These findings support the use of parasagittal ILESIs in cases of unilateral or dominant-side radicular pain. For patients with significant bilateral symptoms, midline ILESIs or bilateral transforaminal injections may be more effective. Further prospective studies are warranted to identify predictors of bilateral relief and optimize procedural technique.