Effect of intravenous methotrexate carried by lipid nanoemulsion in patients with anterior ST-elevation myocardial infarction
In patients with STEMI, LDE-MTX appears to be safe but did not influence LVEDV and other LVR parameters, although it possibly reduced infarct size at 90 days. These hypothesis-generating results support further investigation of a novel nanomedicine approach to STEMI in larger trials.
Authors
- José Carlos Nicolau (ORCID: https://orcid.org/0000-0002-9680-3689)
- Marc S. Sabatine (ORCID: https://orcid.org/0000-0002-0691-3359)
- Talia Falcão Dalçóquio (ORCID: https://orcid.org/0000-0002-0525-0506)
- Gabriela Liberato (ORCID: https://orcid.org/0000-0002-6268-8838)
- Luciano Baracioli
- Aline Ferrari (ORCID: https://orcid.org/0000-0001-6141-8759)
- Carlos Eduardo Rochitte (ORCID: https://orcid.org/0000-0003-4505-3344)
- Robert P. Giugliano (ORCID: https://orcid.org/0000-0003-4110-7675)
- Carlos Alberto Kenji Nakashima
- Roberto R. Giraldez (ORCID: https://orcid.org/0000-0002-1838-9902)
- Raul Cavalcante Maranhão (ORCID: https://orcid.org/0000-0003-1520-4914)
- Thauany Martins Tavoni
- Felipe Gallego Lima (ORCID: https://orcid.org/0000-0003-1204-5743)
- Aleksandra T. Morikawa (ORCID: https://orcid.org/0000-0002-1105-3365)
- Roberto Kalil Filho (ORCID: https://orcid.org/0000-0002-1033-3672)
- Rocío Salsoso
- César Higa Nomura (ORCID: https://orcid.org/0000-0002-7131-6614)
- Paul M. Ridker (ORCID: https://orcid.org/0000-0003-1249-4522)
- Vanessa Maria Gomes Taques Baldo
- Remo H.M. Furtado
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Thrombolysis in Myocardial Infarction Study Group (US)
Publication Details
- Journal
- IJC Heart & Vasculature
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1016/j.ijcha.2025.101771
- Citations
- 1
- Primary Topic
- Acute Myocardial Infarction Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico