Down‐Regulation of Klotho/FGF23 by Low‐Expressed VEGFR2 Inhibits the GH/IGF‐1/PI3K/AKT Signaling Pathway Inducing Intrauterine Growth Restriction in Rats
IUGR caused by a low protein diet reduced birth weight and crown-rump length and low expression of Klotho, FGF23, and VEGFR2 in placental tissues, which may inhibit fetal growth through the VEGFR2-Klotho-FGF23-GH-IGF-1-PI3K-AKT signaling axis.
Authors
- Linfeng Zheng (ORCID: https://orcid.org/0000-0001-9889-4919)
- Yaying Cheng (ORCID: https://orcid.org/0000-0001-8889-3509)
- Li Zhang (ORCID: https://orcid.org/0000-0003-1620-1512)
Institutions
- Hebei North University (CN)
- Hebei General Hospital (CN)
Publication Details
- Journal
- American Journal of Reproductive Immunology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/aji.70110
- Citations
- 1
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Natural Science Foundation of Hebei Province