Leptin and adiponectin in children and young persons with congenital adrenal hyperplasia
Our findings indicate a decrease in leptin with the HC dose, consistent with a detrimental effect of glucocorticoid on satiety and hunger pathways in CAH. Adiponectin was decreased in patients with increased androgens concentrations, suggesting it may be used as an indicator of metabolic risk associated with poor hormonal CAH control.
Authors
- Nils Krone (ORCID: https://orcid.org/0000-0002-3402-4727)
- Justin H. Davies (ORCID: https://orcid.org/0000-0001-7560-6320)
- Leena Patel (ORCID: https://orcid.org/0000-0003-3998-736X)
- S. Faisal Ahmed (ORCID: https://orcid.org/0000-0003-0689-5549)
- Evelien F. Gevers (ORCID: https://orcid.org/0000-0002-4397-4126)
- Neil Lawrence (ORCID: https://orcid.org/0000-0002-7686-6172)
- Tabitha Randell (ORCID: https://orcid.org/0000-0002-1703-1589)
- Mehul Dattani (ORCID: https://orcid.org/0000-0002-0365-5809)
- Brian George Keevil (ORCID: https://orcid.org/0000-0002-0684-9318)
- Ruth Krone (ORCID: https://orcid.org/0000-0003-1201-8788)
- Allan Lawrie (ORCID: https://orcid.org/0000-0003-4192-9505)
- Elizabeth Crowne (ORCID: https://orcid.org/0000-0001-5828-0410)
- Irina Bacila (ORCID: https://orcid.org/0000-0001-7726-4299)
- Urmi Das (ORCID: https://orcid.org/0000-0003-3624-8780)
- Sabah Alvi
- Fiona Ryan
- Timothy Cheetham
Institutions
- Leeds General Infirmary (GB)
- Nottingham University Hospitals NHS Trust (GB)
- University of Liverpool (GB)
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- Great Ormond Street Hospital (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Southampton General Hospital (GB)
- Bristol Royal Hospital for Children (GB)
- Nottingham City Hospital (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- Children's of Alabama (US)
- Manchester University NHS Foundation Trust (GB)
- Birmingham Women's Hospital (GB)
- Birmingham Children's Hospital (GB)
- Lung Institute (US)
- NIHR Southampton Biomedical Research Centre (GB)
- Great North Children's Hospital (GB)
- Oxford University Hospitals NHS Trust (GB)
- William Harvey Research Institute (GB)
- Alder Hey Children's Hospital (GB)
- Royal Manchester Children's Hospital (GB)
- University of Southampton (GB)
- University College London (GB)
- University of Glasgow (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1093/ejendo/lvaf165
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- British Heart Foundation