Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, <scp>DFT</scp> Calculations, and In Vitro Validation
Computational analyses identified flavonoids, particularly Kaempferol glycosides, as potential Akt1 inhibitors with significantly higher predicted binding affinities than Ipatasertib. These findings warrant further exploration of the therapeutic potential of flavonoids for cancers driven by Akt1 hyperactivation.
Authors
- Shokoofeh Jamshidi (ORCID: https://orcid.org/0000-0002-0646-1882)
- Setareh Shojaei (ORCID: https://orcid.org/0000-0001-8323-1231)
- Mehran Feizi‐Dehnayebi (ORCID: https://orcid.org/0000-0002-7868-9085)
- Amir Taherkhani (ORCID: https://orcid.org/0000-0002-6546-8785)
- Ali Eghbalian
Institutions
- Hamedan University of Medical Sciences (IR)
- Alzahra University (IR)
Publication Details
- Journal
- Cancer Reports
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/cnr2.70315
- Citations
- 11
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- Hamadan University of Medical Sciences