A Prenatal Ultrasound Study of Cerebral Cortical Sulci and Gyri Development in Fetuses With Overgrowth Syndrome and/or Cerebral Malformations due to Abnormalities in <i>MTOR</i> Pathway Genes
The integration of 2D imaging and 3D-ICRV technology enables comprehensive prenatal assessment of sulco-gyral development. Our findings highlight the utility of this approach in detecting mTOR-related cortical dysplasias, particularly in cases with atypical Sylvian fissure or POS hypoplasia.
Authors
- Bingguang Liu
- Caiqun Luo (ORCID: https://orcid.org/0009-0006-3038-0931)
- Shengli Li (ORCID: https://orcid.org/0000-0003-0605-8089)
- Qiong Zhen
- Huaxuan Wen (ORCID: https://orcid.org/0000-0001-6944-883X)
- Yang Liu (ORCID: https://orcid.org/0000-0001-9605-7877)
- Hui Wang (ORCID: https://orcid.org/0000-0002-6119-5994)
- Liyuan Chen (ORCID: https://orcid.org/0000-0002-2837-0527)
- Xiaoxia Wu (ORCID: https://orcid.org/0000-0002-8549-6361)
Institutions
- Shenzhen Maternity and Child Healthcare Hospital (CN)
Publication Details
- Journal
- Molecular Genetics & Genomic Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/mgg3.70130
- Citations
- 1
- Primary Topic
- Genetic Syndromes and Imprinting
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Sanming Project of Medicine in Shenzhen