Tumor-Derived CCL16 Normalizes Tumor Vasculature through Macrophage ICAM-1 Receptor and Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma
CCL16 regulates IL24 secretion by macrophages to promote vascular normalization and immune infiltration in hepatocellular carcinoma, which can be harnessed using DPP4 inhibition to enhance the efficacy of immunotherapy.
Authors
- Kunling Chen
- Zhoubin Feng (ORCID: https://orcid.org/0009-0001-5217-1835)
- Mingxin Pan (ORCID: https://orcid.org/0000-0002-9133-3323)
- Xiangxu Wei
- Jingyuan Pei (ORCID: https://orcid.org/0009-0009-4427-4680)
- Yuyan Xu
- Zhuohao Chen
- Yujie Zhang (ORCID: https://orcid.org/0000-0001-9429-5193)
- Yong Li (ORCID: https://orcid.org/0000-0003-1799-4841)
- Liang Zhao (ORCID: https://orcid.org/0000-0002-1429-0884)
- Lei Cai (ORCID: https://orcid.org/0000-0003-1658-7996)
- Huolun Feng (ORCID: https://orcid.org/0009-0004-4315-3039)
Institutions
- Guangdong General Hospital (CN)
- Nanfang Hospital (CN)
- Zhujiang Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4323
- Citations
- 4
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 4.18