Detection of EEG dynamic complex patterns in disorders of consciousness
Diagnosing Disorders of Consciousness (DoC) remains a critical challenge in cognitive neuroscience. In this study we introduce Electroencephalography (EEG)-based brain states as a real-time, bedside tool for assessing dynamic brain connectivity in DoC patients. We analyze EEG data from 237 acute and chronic DoC patients across three centers, identifying five recurrent functional connectivity patterns. The probability of these patterns correlated strongly with consciousness levels, with high-entropy patterns exclusive to healthy controls and low-entropy patterns prevalent in severe DoC, predicting individual recovery outcomes. Real-time testing validated reliable bedside detection of these patterns. Our findings demonstrate EEG's potential for monitoring dynamic brain connectivity, offering insights into the neural basis of consciousness and advancing diagnostic strategies for DoC.
Authors
- Jacobo Diego Sitt (ORCID: https://orcid.org/0000-0002-3878-4846)
- Di Zang (ORCID: https://orcid.org/0000-0003-1400-2747)
- Peng Gui
- Xuehai Wu
- Gabriel Della Bella (ORCID: https://orcid.org/0000-0001-8433-0725)
- Pablo Barttfeld (ORCID: https://orcid.org/0000-0001-8530-6938)
- Dragana Manasova (ORCID: https://orcid.org/0000-0002-2756-3263)
- Diego M. Mateos (ORCID: https://orcid.org/0000-0002-1953-0875)
- Stein Silva (ORCID: https://orcid.org/0000-0001-9690-7413)
- Tristán Bekinschtein (ORCID: https://orcid.org/0000-0001-5501-8628)
- Liping Wang (ORCID: https://orcid.org/0000-0001-8343-7598)
- Fabrice Ferré (ORCID: https://orcid.org/0000-0002-7148-6840)
- Ying Mao (ORCID: https://orcid.org/0000-0001-8055-115X)
- Pedro W. Lamberti (ORCID: https://orcid.org/0000-0002-6659-4214)
- Benjamine Sarton
Institutions
- Jagiellonian University (PL)
- Centre National de la Recherche Scientifique (FR)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Inserm (FR)
- Universidad Nacional de Córdoba (AR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Chinese Academy of Sciences (CN)
- Université Paris Cité (FR)
- University of Cambridge (GB)
- Fudan University (CN)
- China-Japan Friendship Hospital (CN)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Center for Excellence in Brain Science and Intelligence Technology (CN)
- Achucarro Basque Center for Neuroscience (ES)
- Hôpital Purpan (FR)
- Cognitive Neuroimaging Lab (FR)
- Institut du Cerveau (FR)
- Shanghai Clinical Research Center (CN)
- Huashan Hospital (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
Publication Details
- Journal
- Communications Biology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1038/s42003-025-08666-9
- Citations
- 2
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Youth Innovation Promotion Association of the Chinese Academy of Sciences
- Agencia Nacional de Promoción Científica y Tecnológica
- China-Japan Friendship Hospital
- Youth Innovation Promotion Association