F18 Promiscuous Epitope of Acr1 Protein of Mycobacterium tuberculosis Induces the Secretion of IL-10 and Tregs but Not IL-6
Our findings suggest that the F18 epitope induces IL-10 production and Treg differentiation while inhibiting CD4+ T cell proliferation and IL-6 secretion, thereby promoting an immunosuppressive environment. Furthermore, this study highlights the possible role of Acr1 and its immunosuppressive epitope F18 as therapeutic agents for inducing suppressive Tregs, which may help in the management of autoimmune diseases.
Authors
- Anupam Bandyopadhyay (ORCID: https://orcid.org/0000-0002-3221-0315)
- Taruna Lamba
- Suneel Prajapati (ORCID: https://orcid.org/0000-0002-5249-9865)
- Arnab Chowdhury (ORCID: https://orcid.org/0000-0003-3342-2237)
- Javed N. Agrewala (ORCID: https://orcid.org/0000-0001-6786-3239)
Institutions
- Indian Institute of Technology Ropar (IN)
Publication Details
- Journal
- Protein and Peptide Letters
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2174/0109298665398349250728195645
- Citations
- 1
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.35