Interleukin-33 promotes lipolysis of adipocytes and protects male mice against obesity via activation of β-adrenergic receptor signaling
We summarized that IL-33 regulated mature adipocyte metabolism and enhanced lipolysis in male mice via activation of the β-AR/cAMP/PKA/HSL signaling pathway. However, given that sex is a significant determinant in obesity, future studies should investigate potential sex-specific effects of IL-33 in metabolic regulation.
Authors
- Jian Lin (ORCID: https://orcid.org/0000-0003-1265-5314)
- Jian Guan (ORCID: https://orcid.org/0000-0002-2847-1627)
- Jingli Lü (ORCID: https://orcid.org/0000-0001-7411-1430)
- Qianjiang Chen
- Rui Ma (ORCID: https://orcid.org/0000-0002-0242-9797)
- Mengfan Li (ORCID: https://orcid.org/0000-0003-1501-9516)
- Ke Ding (ORCID: https://orcid.org/0000-0002-0476-2710)
Institutions
- Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- International Journal of Obesity
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1038/s41366-025-01873-8
- Citations
- 1
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China