Low Intrinsic Killing Activity and no Impact of Its Positivity on Phase 3 Pneumococcal Vaccine Adult Studies
Thus, eliminating the IK assay as a requirement for OPA testing could be considered in healthy adult populations where antibiotic use is well-regulated.
Authors
- Robert L. Burton (ORCID: https://orcid.org/0000-0002-3086-6476)
- Heather Platt (ORCID: https://orcid.org/0000-0002-0910-6077)
- Ulrike K. Buchwald (ORCID: https://orcid.org/0000-0002-6671-0115)
- Katrina M. Nolan (ORCID: https://orcid.org/0000-0001-5030-7930)
- Weifeng Xu (ORCID: https://orcid.org/0000-0001-7598-1489)
- Marie Bonhomme (ORCID: https://orcid.org/0000-0001-8353-5913)
- David C. LaFon (ORCID: https://orcid.org/0000-0001-5174-1931)
- Kasia Marullo
- Yawen Cheng (ORCID: https://orcid.org/0000-0001-7112-8835)
- Joseph M. Antonello (ORCID: https://orcid.org/0000-0003-0160-7456)
- Jennifer L. Nguyen
- Moon H. Nahm (ORCID: https://orcid.org/0000-0002-6922-1042)
- Chaoyang Ma (ORCID: https://orcid.org/0000-0002-4106-9712)
- Roy Helmy
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- University of Alabama at Birmingham (US)
- Thermo Fisher Scientific (United States) (US)
- Agenta Biotechnologies (United States) (US)
- Thermo Fisher Scientific (Israel) (IL)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1093/infdis/jiaf427
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00