Ultrasonographic Features of Amyloid Arthropathy in Light ChainAmyloidosis: A Case Report

This case underscored key ultrasonographic features of amyloid arthropathy, including synovial thickening with heterogeneous echogenic deposits, tenosynovitis, and subacromialsubdeltoid bursa involvement. Unlike rheumatoid arthritis, amyloidosis lacked erosions and power Doppler signal, highlighting imaging distinctions. The hypoechoic inguinal amyloidoma with calcifications further aligned with amyloid deposition. Although amyloidosis shares certain clinical features with dialysis-related β2-microglobulin amyloidosis (e.g., carpal tunnel syndrome, shoulder deposits), AL amyloidosis may exhibit unique patterns, such as diffuse synovial infiltration without hyperemia. However, ultrasound's non-specificity necessitates histopathological confirmation. While systemic amyloidosis requires pathological confirmation, ultrasonography provides a rapid, cost-effective tool for early diagnostic guidance.

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Journal
Current Rheumatology Reviews
Published
2025-06-27
DOI
https://doi.org/10.2174/0115733971366804250619214510
Primary Topic
Amyloidosis: Diagnosis, Treatment, Outcomes
Type
article
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article

Ultrasonographic Features of Amyloid Arthropathy in Light ChainAmyloidosis: A Case Report

Malek Dhifallah, I. Gharsallah
Current Rheumatology Reviews
Amyloidosis: Diagnosis, Treatment, Outcomes
article

Ultrasonographic Features of Amyloid Arthropathy in Light ChainAmyloidosis: A Case Report

Malek Dhifallah, I. Gharsallah
article en

Abstract

This case underscored key ultrasonographic features of amyloid arthropathy, including synovial thickening with heterogeneous echogenic deposits, tenosynovitis, and subacromialsubdeltoid bursa involvement. Unlike rheumatoid arthritis, amyloidosis lacked erosions and power Doppler signal, highlighting imaging distinctions. The hypoechoic inguinal amyloidoma with calcifications further aligned with amyloid deposition. Although amyloidosis shares certain clinical features with dialysis-related β2-microglobulin amyloidosis (e.g., carpal tunnel syndrome, shoulder deposits), AL amyloidosis may exhibit unique patterns, such as diffuse synovial infiltration without hyperemia. However, ultrasound's non-specificity necessitates histopathological confirmation. While systemic amyloidosis requires pathological confirmation, ultrasonography provides a rapid, cost-effective tool for early diagnostic guidance.

Current Rheumatology ReviewsVol. 21
Military Hospital of Tunis (TN), Tunis El Manar University (TN)
Openalex Percentile: Top 82%
Amyloidosis: Diagnosis, Treatment, Outcomes
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Ultrasonographic Features of Amyloid Arthropathy in Light ChainAmyloidosis: A Case Report — Malek Dhifallah, I. Gharsallah · Current Rheumatology Reviews (2025) | TGRS Research Map | TGRS