Hydroxychloroquine reduces metastatic tumor burden in pancreatic adenocarcinoma through myeloperoxidase inhibition
Hydroxychloroquine suppressed pancreatic metastases growth through myeloperoxidase inhibition, leading to a significant increase in survival. Corroborative data supports this mechanism in metastatic pancreatic adenocarcinoma patients treated with hydroxychloroquine. These data provide important insight into the role of myeloperoxidase in pancreatic metastases and the potential use of hydroxychloroquine in metastatic pancreatic adenocarcinoma treatment.
Authors
- Pavan Rao
- Tracy Liu (ORCID: https://orcid.org/0000-0003-0671-8390)
- Brian A. Boone (ORCID: https://orcid.org/0000-0001-9006-059X)
- Angisha Basnet (ORCID: https://orcid.org/0000-0002-9000-9062)
- Britney Niemann
- Werner J. Geldenhuys (ORCID: https://orcid.org/0000-0002-2405-376X)
- Kaitlyn M. Landreth
- Quinn Hopen (ORCID: https://orcid.org/0000-0003-2911-8216)
Institutions
- West Virginia University (US)
- West Virginia University Hospitals (US)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1186/s12950-025-00456-8
- Citations
- 2
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Institutes of Health
- National Cancer Institute
- National Institute of General Medical Sciences