Moderate Beer Consumption Ameliorated Aging‐Related Metabolic Disorders Induced by D‐Galactose in Mice via Modulating Gut Microbiota Dysbiosis

The process of aging is a multifaceted physiological phenomenon that entails the gradual deterioration of physical health. In recent years, fermented foods have garnered significant attention for their potential anti-aging benefits; however, the effects of moderate consumption of beer on aging-related metabolic disorders remain unexplored. Original beer, India Pale Ale (IPA), and Stout are widely consumed alcoholic beverages on a global scale. The objective of this study is to investigate and compare the effect of moderate consumption of these beers on aging-related metabolic disorders in mice induced by D-galactose (D-gal), encompassing inflammation, organ impairment, oxidative stress, and dyslipidemia. Furthermore, potential mechanisms were elucidated through analysis of gut microbiota. Compared to the Original beer, oral administration of IPA and Stout effectively improved liver and kidney health in mice. All beers mitigated serum oxidative damage induced by D-gal, with Stout exhibiting a more significant effect. Additionally, the Original beer was more effective at restoring intestinal microbiota diversity. Moreover, the tested beers elicited modifications in the composition of intestinal microbiota, including a decline in Firmicutes abundance and an elevation in Bacteroidota levels, accompanied by a decrease in harmful bacteria like Deferribacterota and an increase in beneficial bacteria like <i>Lactobacillus</i> and <i>Roseburia</i>. The research findings suggest that moderate consumption of Original beer, IPA, and Stout possesses the potential to mitigate D-gal-induced metabolic disorders through modulation of gut microbiota dysbiosis. Consequently, these results provide valuable insights into the favorable impacts associated with moderate beer consumption on human aging and health.