Combined cryotherapy and photodynamic therapy for recurrent generalized giant plantar warts: A case report

Our case demonstrates that multimodal therapy combining liquid nitrogen cryotherapy with photodynamic therapy (PDT) achieves complete and durable clearance of extensive, hyperkeratotic plantar warts, with no recurrence observed over a two-year follow-up.The combination of cryotherapy, PDT, and immunomodulation demonstrates superior efficacy for recalcitrant giant plantar warts compared to conventional therapies. This approach minimizes recurrence, reduces scarring, and enhances tissue repair, offering a promising first-line strategy for complex cases.