Lifestyle, genetic risk, plasma pTau217, and incident cognitive impairment in WRAP
Healthier lifestyle is associated with reduced risk of incident impairment. Apolipoprotein E (APOE) ε4 allele carriage and pTau217 are associated with higher risk of incident impairment. No significant lifestyle risk by APOEε4 nor pTau217 interactions were observed. Combined lifestyle tertiles and APOEε4 carriage increased risk monotonically. Lifestyle tertiles increased impairment risk monotonically across pTau217 groups.
Authors
- Bruce P. Hermann (ORCID: https://orcid.org/0000-0003-0133-4427)
- Rachel Studer (ORCID: https://orcid.org/0000-0002-4321-6210)
- Rebecca L. Koscik (ORCID: https://orcid.org/0000-0003-0025-744X)
- Erin M. Jonaitis (ORCID: https://orcid.org/0009-0004-5091-8255)
- Rachael E. Wilson (ORCID: https://orcid.org/0000-0003-4197-7777)
- Karly Alex Cody (ORCID: https://orcid.org/0000-0001-5996-2560)
- Julie Elisabeth Oomens (ORCID: https://orcid.org/0000-0002-5201-8080)
- Nathaniel A. Chin (ORCID: https://orcid.org/0000-0001-8008-9356)
- Ramiro Eduardo Rea Reyes (ORCID: https://orcid.org/0000-0001-9749-282X)
- Kimberly D. Mueller (ORCID: https://orcid.org/0000-0001-8691-9517)
- Sterling C. Johnson
Institutions
- University of Wisconsin–Madison (US)
- University of Wisconsin Health (US)
- Wisconsin Division of Public Health (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70573
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging