HbH Disease in an Elderly Man Due to Compound Heterozygosity for Deletional α-Thalassemia and Hb Dubai ( <i>HBA2</i> :c.368A > T)
HbH disease may rarely be caused by a combination of deletional α-thalassemia and an unstable α-globin chain variant. Diagnosis is challenging and may be delayed in cases with mild symptoms. Hemoglobin Dubai is an unstable α-globin chain variant that was previously reported to be asymptomatic. We report the case of a 74-year-old man with mild HbH disease due to compound heterozygosity for Hemoglobin Dubai with deletional α-thalassemia.
Authors
- Prasad Dange (ORCID: https://orcid.org/0000-0002-7187-6021)
- Rituparna Chetia (ORCID: https://orcid.org/0000-0002-6972-2365)
- Sankappa P Sinhasan (ORCID: https://orcid.org/0000-0003-0752-0853)
- Prashant Sharma (ORCID: https://orcid.org/0000-0003-4741-3403)
- Jasbir Kaur Hira
- Roopam Deka (ORCID: https://orcid.org/0000-0001-9899-758X)
- T. Devi (ORCID: https://orcid.org/0000-0002-2135-5535)
- Sanjeev Chhabra
Institutions
- All India Institute of Medical Sciences Guwahati (IN)
- Post Graduate Institute of Medical Education and Research (IN)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Hemoglobin
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1080/03630269.2025.2544838
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00