An Advanced Network Pharmacology Study Reveals the Multi-Pathway and Multi-Gene Regulatory Mechanism of Jinbai Heat-clearing Prescription in HPV-induced Cervical Cancer via Molecular Docking and Microarray Data Analysis
This study provides the first systematic evidence of JBHCP's multi-pathway mechanism against HPV-associated cervical cancer, emphasizing CDK1/2 inhibition as a key therapeutic strategy. JBHCP727 emerges as a promising lead compound. Further in vivo and clinical validation is warranted to translate these findings into clinical applications.
Authors
- Sui Liu
- Jianning He (ORCID: https://orcid.org/0000-0002-9657-9752)
- C Yue
- Shiou Yih Lee (ORCID: https://orcid.org/0000-0001-9493-1436)
- Yangyang Liu (ORCID: https://orcid.org/0000-0001-8547-0172)
- Zhang‐Xin Yu
- Zixiao Jiang (ORCID: https://orcid.org/0009-0002-6061-420X)
- Xiang-Xin Niu
Institutions
- INTI International University (MY)
- Hainan Normal University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Marion General Hospital (US)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-08-08
- DOI
- https://doi.org/10.2174/0109298673377164250710100915
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00