Ceftazidime-Induced Overexpression of MexJK-OprM Confers Resistance to Ceftolozane/Tazobactam in an Isolate of Pseudomonas aeruginosa
This study demonstrated that overexpression of the MexJK-OprM efflux pump is a key mechanism underlying TAZ/CTLZ resistance. In addition, prior administration of CAZ contributed to the acquisition of resistance, highlighting the need to consider the risk of resistance acquisition when switching antibiotics. In such cases, the choice of carbapenems should be considered.
Authors
- Shigeru Fujimura (ORCID: https://orcid.org/0000-0002-7419-3293)
- SHIN IKEJIMA
- Hajime Nakai
- Fumihiko Okumura
- M. Kawamura (ORCID: https://orcid.org/0000-0003-1863-1241)
- Takumi Sato (ORCID: https://orcid.org/0000-0003-4277-0583)
- Mai Tamura
- Kei Kaimori
Institutions
- Odawara Municipal Hospital (JP)
- Tohoku Medical and Pharmaceutical University Hospital (JP)
- Tohoku Medical and Pharmaceutical University (JP)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/idr.s540567
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00