Improving 5-Aminolevulinic acid photodynamic therapy through the modulation of iron metabolism
This study offers a novel strategy for improving the efficacy of ALA-PDT through the modulation of iron metabolism, achieved by targeting DMT1 and utilizing the iron chelator DFO. Additionally, DFO exhibited a dual mechanism, depending on cellular iron homeostasis.
Authors
- Ogura Shun-Ichiro
- Li Chenhan
Institutions
- Tokyo Institute of Technology (JP)
- Life Science Institute (JP)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1016/j.pdpdt.2025.104755
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00