PET Imaging of Diabetes-Induced Alterations in Metabolism and Immune Activation
PET imaging reveals that obesity and T2D alter glucose metabolism and immune activation while suppressing tumor-immune activation in diabetic obese mice both within the tumor microenvironment and systemically.
Authors
- Patrick N. Song (ORCID: https://orcid.org/0000-0002-1545-0886)
- Heba M. Alsheikh
- Shannon E. Lynch (ORCID: https://orcid.org/0000-0002-0325-2823)
- Anna G. Sorace (ORCID: https://orcid.org/0000-0002-3640-3966)
- Benjamin M. Larimer (ORCID: https://orcid.org/0000-0002-1288-7206)
- Lalita A. Shevde (ORCID: https://orcid.org/0000-0002-1520-1476)
- Clayton Clopton Yates (ORCID: https://orcid.org/0000-0001-5420-9852)
- Suzanne E. Lapi (ORCID: https://orcid.org/0000-0003-0090-0191)
- Candace C. Parker (ORCID: https://orcid.org/0000-0001-6744-7438)
- Yujun Zhang (ORCID: https://orcid.org/0000-0002-8816-7694)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of Alabama at Birmingham Hospital (US)
- Johns Hopkins University (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1007/s11307-025-02027-y
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for the National Institutes of Health
- National Institutes of Health
- National Cancer Institute
- National Institute of General Medical Sciences