<i>Staphylococcus pseudintermedius</i> isolated from atopic dogs with pyoderma induces mast cell degranulation
<i>S. pseudintermedius</i> isolates from atopic dogs carry genes encoding δ-toxin, a staphylococcal exotoxin that can degranulate murine mast cells <i>in vitro</i>. An agent in filtered <i>S. pseudintermedius</i> culture known to contain δ-toxin causes degranulation of dermal mast cells <i>in vivo</i> and may play a role in the initiation and/or exacerbation of cAD.
Authors
- Yuumi Nakamura (ORCID: https://orcid.org/0000-0001-6256-8302)
- A. L. Bell (ORCID: https://orcid.org/0000-0001-6889-7094)
- Richard G. Langley (ORCID: https://orcid.org/0000-0003-4730-2164)
- Martin Middleditch (ORCID: https://orcid.org/0000-0001-7077-5897)
- Yuki Katayama (ORCID: https://orcid.org/0000-0002-7940-2322)
- Michael Hardcastle
Institutions
- University of Auckland (NZ)
- Carleton College (US)
- St John New Zealand (NZ)
- Biocompatibles (United Kingdom) (GB)
- The University of Osaka (JP)
Publication Details
- Journal
- New Zealand Veterinary Journal
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1080/00480169.2025.2543031
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00