Phenotypic clusters of long-term damage in Sjögren’s disease: a 15-year multicentre study
In a multicentre Italian SjD cohort, the largest damage burden develops by year 5 and progressively builds up over at least 15 years with different progression pattern among damage domains. Disease activity at diagnosis and lymphadenopathy significantly predict damage. Five clusters with distinct damage patterns were identified, suggesting a tailored approach to the disease since diagnosis to reduce long-term damage accrual.
Authors
- Elena Bartoloni (ORCID: https://orcid.org/0000-0003-4776-2136)
- Gaetano La Rocca (ORCID: https://orcid.org/0000-0002-1808-7090)
- Marta Mosca (ORCID: https://orcid.org/0000-0001-5937-4574)
- Lorenza Bruno (ORCID: https://orcid.org/0000-0002-2849-145X)
- Giacomo Cafaro (ORCID: https://orcid.org/0000-0003-1774-1916)
- Giovanni Fulvio (ORCID: https://orcid.org/0000-0003-0130-4412)
- Chiara Baldini (ORCID: https://orcid.org/0000-0002-4454-1824)
- Roberto Gerli (ORCID: https://orcid.org/0000-0002-4684-575X)
- Roberto Dal Pozzolo
- Carlo Perricone (ORCID: https://orcid.org/0000-0003-4771-6981)
- Francesco Ferro (ORCID: https://orcid.org/0000-0003-2834-9768)
- B. Dei
Institutions
- University of Pisa (IT)
- University of Perugia (IT)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1093/rheumatology/keaf434
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00