Impact of Aromatase Inhibition on Bone Mineral Density and Structure: A Randomized Controlled Trial in Boys With Delayed Puberty
Testosterone treatment increased bone formation markers and predicted greater BMC accrual than Lz at metabolically active skeletal sites. These findings reinforce the anabolic role of androgens, partly mediated by estrogens, in early pubertal bone development. A short, 6-month treatment with Lz did not appear detrimental to bone accrual based on pQCT parameters. However, these findings do not allow conclusions regarding skeletal safety of longer Lz use.
Authors
- Matti Hero (ORCID: https://orcid.org/0000-0002-9843-5082)
- Hanna Huopio
- Päivi J. Miettinen (ORCID: https://orcid.org/0000-0002-5184-9616)
- Sirpa Tenhola
- Tero Varimo (ORCID: https://orcid.org/0000-0002-6294-4563)
- Toni Rikkonen (ORCID: https://orcid.org/0000-0001-5948-1222)
- Taneli Raivio (ORCID: https://orcid.org/0000-0001-5385-434X)
- Raimo Voutilainen (ORCID: https://orcid.org/0000-0002-7858-665X)
Institutions
- University of Helsinki (FI)
- University of Eastern Finland (FI)
- Helsinki University Hospital (FI)
- Helsinki Children's Hospital (FI)
- Kuopio University Hospital (FI)
- Finland University (FI)
- Kymenlaakson keskussairaala (FI)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1093/ejendo/lvaf160
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00