Serotonin Metabolism Shapes the Tumor Immune Microenvironment and Serves as aTherapeutic Target in Lung Cancer
Serotonin deficiency in the tumor microenvironment of the lung suppresses antitumor immunity. Its restoration reverses immune dysfunction and limits tumor progression. These findings identify serotonin as a potential metabolic regulator and immunotherapeutic target in lung cancer.
Authors
- Likun Zhuang (ORCID: https://orcid.org/0000-0003-3002-2406)
- Jie Jia (ORCID: https://orcid.org/0000-0002-4516-4629)
- Wen‐Hui Shen (ORCID: https://orcid.org/0000-0001-7988-6382)
- Naikun Sun (ORCID: https://orcid.org/0000-0002-1299-7181)
- Miersalijiang Yasen
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Wei Hong
- Junxia Huang (ORCID: https://orcid.org/0000-0003-4084-9159)
Institutions
- Fudan University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-08-08
- DOI
- https://doi.org/10.2174/0118715206408134250801050919
- Citations
- 2
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 2.94