Roles of TEAD Transcription Factors and their Coactivators in the Progression and Metastasis of Cancers

The transcriptional enhanced associate domain (TEAD) family of transcription factors and their coactivators play pivotal roles in the Hippo-YAP/TAZ pathway, a critical regulatory axis involved in oncogenesis and tumor progression. To investigate the functional interactions of TEAD transcription factors, we performed comprehensive analyses of gene regulatory networks associated with TEADs. TEADs regulate oncogenesis and tumor progression through interactions with upstream oncogenic signaling pathways and the regulation of downstream target genes. As pivotal transcription factors, TEADs critically regulate multiple oncogenic processes, including epithelial-mesenchymal transition (EMT), proliferation, apoptosis, migration, invasion, metastasis, and aerobic glycolysis in cancer cells. TEADs are regulated by numerous non-coding RNAs [ncRNAs] through the Hippo, AKT, and TGF-β signaling pathways in cancers. These insights establish a strong molecular rationale for developing TEAD-targeted therapeutic strategies in cancer treatment.