Exploring the Causal Relationship Between Saliva Microbiota Abundance and Chronic Obstructive Pulmonary Disease/Idiopathic Pulmonary Fibrosis: A Two-Sample Mendelian Randomization Study

This exploratory study suggests potential directional associations between specific salivary microbiota and chronic respiratory diseases. <i>Parvula</i> abundance may be protective against COPD, while Bacilli, <i>Porphyromonas</i>, and <i>Fusobacterium</i> may influence IPF risk. These findings support the salivary microbiome as a potential contributor to respiratory disease pathogenesis and warrant further validation in mechanistic and longitudinal studies.