Longitudinal profiles of fecal calprotectin and C-reactive protein in relation to outcomes in Crohn’s disease patients on infliximab
Patients under IFX therapy with near or above-threshold FCAL levels or a history of high CRP were more likely to experience adverse outcomes. Regression analyses demonstrated that class membership provided additional prognostic value beyond baseline variables alone. These findings highlight the clinical relevance of trajectory-based monitoring for optimizing treatment strategies and underscore the importance of controlling inflammation early to prevent disease progression in CD.
Authors
- Samuel Fernandes (ORCID: https://orcid.org/0000-0002-2947-8791)
- Bruna Domingues
- Joana Moleiro
- Cláudia Camila Dias (ORCID: https://orcid.org/0000-0001-9356-3272)
- Mafalda Santiago (ORCID: https://orcid.org/0000-0001-8893-4307)
- Bruno Arroja
- María Manuela Estevinho (ORCID: https://orcid.org/0000-0001-7171-0139)
- Laurent Peyrin‐Biroulet (ORCID: https://orcid.org/0000-0003-2536-6618)
- Joana Roseira (ORCID: https://orcid.org/0000-0002-5098-8729)
- Irina Mocanu (ORCID: https://orcid.org/0000-0001-5176-9344)
- Isadora Rosa (ORCID: https://orcid.org/0000-0002-2953-5987)
- Silvio Danese (ORCID: https://orcid.org/0000-0001-7341-1351)
- Sandra Fernandes Dias (ORCID: https://orcid.org/0000-0002-3146-5164)
- Fernando Magro (ORCID: https://orcid.org/0000-0003-2634-9668)
- Eugénia Cancela
- Paula Ministro (ORCID: https://orcid.org/0000-0003-2439-9522)
- Francisco Portela (ORCID: https://orcid.org/0000-0002-7593-6124)
- Paula Sousa (ORCID: https://orcid.org/0000-0002-9009-9635)
- Joana Castela (ORCID: https://orcid.org/0000-0001-7551-1591)
- Marta Patita (ORCID: https://orcid.org/0000-0003-1726-2528)
- Helena Tavares de Sousa (ORCID: https://orcid.org/0000-0002-6626-205X)
- Luís Correia (ORCID: https://orcid.org/0000-0002-3443-5366)
- Paula Lago
- Ana Vieira
Institutions
- Humanitas University (IT)
- University of Lisbon (PT)
- Inserm (FR)
- Universidade do Porto (PT)
- Portuguese Army (PT)
- Hospital de São João (PT)
- Centro Hospitalar Tondela-Viseu (PT)
- CUF Porto Hospital (PT)
- SGS (Portugal) (PT)
- Algarve Biomedical Center (PT)
- Decision Sciences (United States) (US)
- Centre for Health Technology and Services Research (PT)
- Hospital Braga (PT)
- Centro Hospitalar de Vila Nova de Gaia (PT)
- Câmara Municipal de Almada (PT)
- Institute of the Pupils of the Army (PT)
- Unidade Hospitalar de Bragança (PT)
- IRCCS Humanitas Research Hospital (IT)
- Nutrition-Génétique et Exposition aux Risques Environnementaux (FR)
- University of Algarve (PT)
- University of Coimbra (PT)
- Université de Lorraine (FR)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf120
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82