A Double‐Humanized Murine Model in Bladder Cancer: A Novel Preclinical Model for Cancer Immunology Research
In summary, this study offers an optimized protocol for the consistent establishment of BC PDX tumors. Furthermore, it has also established a novel double-humanized model, demonstrating the potential for drug screening and clinical prognosis in the context of BC treatment.
Authors
- Robert S. Svatek (ORCID: https://orcid.org/0000-0002-0239-1338)
- Niannian Ji
- Jaime Furman
- Neelam Mukherjee (ORCID: https://orcid.org/0000-0003-1974-6075)
- Shaun Trecarten (ORCID: https://orcid.org/0009-0002-0968-6339)
- Tyler Jay Curiel (ORCID: https://orcid.org/0000-0001-6962-9411)
- Zaineb Hassouneh (ORCID: https://orcid.org/0000-0002-2919-7164)
- Zhen‐Ju Shu
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- Urology San Antonio (US)
- Mays Cancer Center at UT Health San Antonio (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/cam4.71150
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Prevention and Research Institute of Texas
- Bladder Cancer Advocacy Network
- National Institutes of Health