Compartment-specific Metabolic Alterations to Insulin Reflect Adiposity-driven Variation and Predict Type 2 Diabetes
Compartment-specific metabolic responses to insulin are shaped by adiposity and predict future T2D risk, supporting use of metabolomic signatures for early identification and prevention.
Authors
- Robert Sladek (ORCID: https://orcid.org/0000-0002-2730-1204)
- Magdalena Sevilla-González (ORCID: https://orcid.org/0000-0001-6135-9998)
- Errol B. Marliss (ORCID: https://orcid.org/0000-0002-2838-0821)
- Sergio A. Burgos (ORCID: https://orcid.org/0000-0003-0569-4307)
- James B. Meigs (ORCID: https://orcid.org/0000-0002-2439-2657)
- Alisa K. Manning (ORCID: https://orcid.org/0000-0003-0247-902X)
- Sarah Hsu (ORCID: https://orcid.org/0000-0001-9823-9711)
- Clary B. Clish (ORCID: https://orcid.org/0000-0001-8259-9245)
- Jesse Islam (ORCID: https://orcid.org/0000-0001-7500-5453)
- Michael A. Tsoukas (ORCID: https://orcid.org/0000-0002-8326-7274)
- Michel Gravel (ORCID: https://orcid.org/0000-0003-3656-7108)
- Charles Kooperberg
- Alexander P. Reiner
- Paul A. Hanson
Institutions
- Broad Institute (US)
- Harvard University (US)
- McGill University Health Centre (CA)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- McGill Genome Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1210/clinem/dgaf454
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81