Impact of intra-articular high-concentration hyaluronic acid administration on the innate immune response in experimental knee osteoarthritis
Intra-articular administration of high concentrations of HA reduced IL-1β concentration in the OA synovium despite no observable improvement in cartilage or synovial lesions was observed. We suggest that the long-term beneficial effect of HA in human OA could be attributed to a "memory fingerprint" in the innate immune response, potentially leading to sustained reduced activity over an extended period of treatment.
Authors
- Alberto Migliore (ORCID: https://orcid.org/0000-0002-3397-6478)
- Aránzazu Mediero (ORCID: https://orcid.org/0000-0002-5368-574X)
- Raquel Largo (ORCID: https://orcid.org/0000-0001-6525-2944)
- Alberto López-Reyes (ORCID: https://orcid.org/0000-0002-2575-2589)
- Miguel Marco-Bonilla (ORCID: https://orcid.org/0009-0005-5103-0327)
- Gabriel Herrero‐Beaumont (ORCID: https://orcid.org/0000-0002-3241-991X)
- Alberto Irigaray-Moreno
Institutions
- Fatebenefratelli Hospital (IT)
- Instituto Nacional de Rehabilitación (MX)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Ospedale San Pietro Fatebenefratelli (IT)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1186/s12891-025-09061-5
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- Comunidad de Madrid
- European Commission
- Instituto de Salud Carlos III