Drug–Drug Interactions and Combination Therapy Strategies of Amiodarone With Digoxin, Rivaroxaban, and Phenytoin Assessed by Physiologically Based Pharmacokinetic Modeling
We have successfully developed PBPK models for AMI, RIV, and PHT. These models effectively simulate the DDIs that occur when AMI is co-administered with DIG, RIV, or PHT, thereby providing guidance for dosing regimens in clinical combination therapies.
Authors
- T.K. Chen (ORCID: https://orcid.org/0009-0009-6252-6589)
- Zhiwei Liu (ORCID: https://orcid.org/0009-0005-2924-2622)
- Yiming Li (ORCID: https://orcid.org/0009-0007-6422-1442)
- Saiya Li (ORCID: https://orcid.org/0009-0004-1710-1999)
- Haitang Xie (ORCID: https://orcid.org/0000-0001-9933-5481)
- Yating Wu (ORCID: https://orcid.org/0009-0009-3032-6996)
- Wenhui Wang (ORCID: https://orcid.org/0009-0009-9986-8558)
- Youjun Chen (ORCID: https://orcid.org/0009-0004-8376-5101)
Institutions
- Wannan Medical College (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1002/phar.70050
- Citations
- 1
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.56