Direction and modality of transcription changes caused by TAD boundary disruption in Slc29a3/Unc5b locus depends on tissue-specific epigenetic context
Disrupting the insulator element between broadly expressed genes resulted in moderate, tissue-dependent transcriptional alterations, rather than uniformly activating or silencing the target genes. These findings show that TAD boundaries contribute to context‑specific regulation even at housekeeping loci and underscore the need for refined models to predict the effects of non‑coding structural variants.
Authors
- Pavel Salnikov (ORCID: https://orcid.org/0000-0001-9470-7178)
- Nikita Torgunakov (ORCID: https://orcid.org/0000-0003-2493-0731)
- Varvara Lukyanchikova (ORCID: https://orcid.org/0000-0002-1828-4721)
- Veniamin Fishman (ORCID: https://orcid.org/0000-0002-5573-3100)
- Polina Belokopytova (ORCID: https://orcid.org/0000-0003-1390-7341)
- Alexandra Yan (ORCID: https://orcid.org/0000-0003-0305-0612)
- Alexey Korablev (ORCID: https://orcid.org/0000-0002-0571-6935)
- Yana Stepanchuk (ORCID: https://orcid.org/0000-0002-5971-1902)
- Savelii Tikhomirov (ORCID: https://orcid.org/0000-0002-3962-9848)
- Emil Viesná
- Irina Serova
Institutions
- Novosibirsk State University (RU)
- Institute of Cytology and Genetics (RU)
- Artificial Intelligence in Medicine (Canada) (CA)
- Novosibirsk State Technical University (RU)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1186/s13072-025-00618-1
- Citations
- 1
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ministry of Education and Science of the Russian Federation
- Russian Science Foundation