Effects of proinflammatory cytokines and programmed cell death on cognitive domains in older age patients with bipolar disorder
This is the first study to simultaneously examine the proinflammatory system and the PD-1/PD-L1 pathway in a clinical OABD sample, with findings suggesting that both systems impact cognitive function in OABD patients. Further research is needed to explore the neuroinflammatory mechanisms underlying BD's neurodegenerative course.
Authors
- Pei‐Ying Lee
- Cho‐Yin Huang (ORCID: https://orcid.org/0000-0002-0274-6645)
- Po‐Hsiu Kuo (ORCID: https://orcid.org/0000-0003-0365-3587)
- Wen-Yin Chen (ORCID: https://orcid.org/0000-0001-5730-9699)
- Shang‐Ying Tsai (ORCID: https://orcid.org/0000-0001-5662-0055)
- Chian‐Jue Kuo (ORCID: https://orcid.org/0000-0002-2773-1335)
- Chih Chiang Chiu
Institutions
- Fu Jen Catholic University (TW)
- National Taiwan University (TW)
- National Taipei University of Nursing and Health Science (TW)
- Taipei Medical University Hospital (TW)
- Taipei City Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Annals of General Psychiatry
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1186/s12991-025-00591-9
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Council