Human Umbilical Cord Mesenchymal Stem Cells Modulate Cytokine Secretion of CD4<sup>+</sup> T Cell in Systemic Lupus Erythematosus by Inhibiting HSP90AA1 in the Glucose‐Activated PI3K‐AKT Pathway
The hUC-MSCs treatment inhibited overactive glucose metabolism of SLE-CD4<sup>+</sup> T cells. HSP90AA1 in the PI3K-AKT pathway induced by the glucose metabolism may be involved in the anti-inflammatory function of hUC-MSCs treatment.
Authors
- Fei Chang (ORCID: https://orcid.org/0000-0003-2927-1544)
- Hongtao Jin (ORCID: https://orcid.org/0000-0002-0638-707X)
- Aijing Liu (ORCID: https://orcid.org/0000-0002-5762-5592)
- Jun Ma (ORCID: https://orcid.org/0000-0003-2843-0769)
- Shaoxin Cui
- Meng Ding
- L. Jin (ORCID: https://orcid.org/0009-0004-3282-233X)
- Jingjing He (ORCID: https://orcid.org/0000-0001-5574-1517)
- Xiaoping Wang (ORCID: https://orcid.org/0000-0001-6265-530X)
- Min Shi (ORCID: https://orcid.org/0000-0002-2130-181X)
- Yiming Yang
- Jingjing Yu (ORCID: https://orcid.org/0000-0002-2408-5809)
- Lin Yang (ORCID: https://orcid.org/0000-0001-5383-4779)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Hebei Science and Technology Department (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/iid3.70239
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hebei Province
- Hebei Medical University