Streptococcus gallolyticus supernatant induces M2 macrophage polarization and activates IL-17 F signaling in colorectal tumorigenesis
Sgsup is associated with CRC progression by promoting cell proliferation and inflammation, facilitating M2 macrophage polarization, and elevating IL-17 F and IL-22 expression. Metabolites such as creatine, along with IL-17 F/IL-22-related signaling pathways, appear to be involved. These findings suggest that both Sg-derived metabolites and host immune signaling may serve as potential targets for CRC intervention. Functional validation of individual metabolites is currently in progress.
Authors
- Haoming Xu (ORCID: https://orcid.org/0000-0002-8131-7477)
- Youlian Zhou (ORCID: https://orcid.org/0000-0002-7107-3288)
- Hailan Zhao (ORCID: https://orcid.org/0000-0001-9330-9741)
- Chen Huang (ORCID: https://orcid.org/0000-0001-6094-1812)
- Min‐zheng Zhu (ORCID: https://orcid.org/0000-0002-1986-6520)
- Jiaqi Wang (ORCID: https://orcid.org/0000-0001-8841-0124)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-1214-7849)
- Yong Zhang
- Yuqiang Nie (ORCID: https://orcid.org/0000-0002-6632-8194)
- Xin Nie (ORCID: https://orcid.org/0000-0001-5774-7576)
- D. W. Luo (ORCID: https://orcid.org/0000-0003-1613-7186)
- Xue Guo (ORCID: https://orcid.org/0000-0003-3533-023X)
- Jing Xu (ORCID: https://orcid.org/0000-0001-6877-3577)
- Wenjing Qiu
Institutions
- Jinan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou First People's Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Gut Pathogens
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1186/s13099-025-00731-2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province