The Role of Functional Brain Connectivity in Intervention Success: A Secondary Analysis from the SYNERGIC Trial
Responders to a physical exercise intervention possess stronger preintervention functional connectivity between regions implicated in higher-order cognitive and behavioral processing. Functional connectivity may delineate who is primed for intervention success and who may require alternative strategies before beginning. Future research should aim to determine if preintervention functional connectivity can help optimize intervention resources and enhance the precision of personalized exercise recommendations.
Authors
- Robert Bartha (ORCID: https://orcid.org/0000-0002-7118-9096)
- Frederico Pieruccini‐Faria (ORCID: https://orcid.org/0000-0002-7659-4285)
- Lindsay S. Nagamatsu (ORCID: https://orcid.org/0000-0002-5444-8965)
- Suzanne T. Witt (ORCID: https://orcid.org/0000-0002-5530-0807)
- Laura Elizabeth Middleton (ORCID: https://orcid.org/0000-0001-8624-3123)
- Quincy J. Almeida (ORCID: https://orcid.org/0000-0002-0806-4397)
- Manuel Montero‐Odasso (ORCID: https://orcid.org/0000-0002-5796-2361)
- Nick W. Bray (ORCID: https://orcid.org/0000-0001-5831-7842)
- Teresa Y L Liu-Ambrose (ORCID: https://orcid.org/0000-0002-8297-5308)
- Louis Bherer
Institutions
- Western University (CA)
- Memorial University of Newfoundland (CA)
- University of British Columbia (CA)
- University of Waterloo (CA)
- London Health Sciences Centre (CA)
- Parkwood Institute (CA)
- Robarts Clinical Trials (CA)
- Wilfrid Laurier University (CA)
Publication Details
- Journal
- Medicine & Science in Sports & Exercise
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1249/mss.0000000000003829
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00